Highly chemoselective copper-catalyzed conjugate reduction of stereochemically labile alpha,beta-unsaturated amino ketones.
نویسندگان
چکیده
Highly chemoselective conjugate reduction of chiral alpha,beta-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.
منابع مشابه
Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones.
A highly regioselective and enantioselective copper-catalyzed 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones was developed. The 1,4-addition products were obtained regioselectively in high yields with up to 98% ee.
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عنوان ژورنال:
- The Journal of organic chemistry
دوره 74 19 شماره
صفحات -
تاریخ انتشار 2009